不知道题主想要表达的“居家办公”是哪个“居家办公”。

work at home 是有在家工作的意思，但是这个“在家工作”可能表示你是自由职业从业者。

如果想表达因为一些特殊情况，比如疫情，而居家办公，这时候的居家办公更有远程办公的意思，这时候译为“work at home”可能就有点指代不明，译为work from home更为合适。

此外，居家办公（远程办公）也有专门的用语：telecommuting或teleworking。

再此外，外刊中常用remote work一词表示居家办公。

可参考Wikipedia对该词的释义：

Remote work, also called work from home (WFH), work from anywhere, telework, remote job, mobile work, and distance work is an employment arrangement in which employees do not commute to a central place of work, such as an office building, warehouse, or retail store. Instead, work can be accomplished in the home, such as in a study, a small office/home office and/or a telecentre. A company in which all workers perform remote work is known as a distributed company.

另附双语例句供参考：

这仅仅是纽约运用居家办公方法 的一例而已，据报告说，总部 设在纽约的所有组织运用这种办法的效果很好。

This is just one example of when telecommuting is used in New York and reportedly it is working well for all New York-based organizations.